Abstract: Objective To analyze the results and pregnancy outcomes of toxoplasma gondii,rubella virus,cytomegalovirus and herpes simplex virus(TORCH) screening among pre-pregnancy and early pregnancy women,and to analyze the clinical significance of TORCH screening in early pregnancy,so as to promote maternal and infant health level and improve the quality of prenatal and postnatal care.Methods A total of 2118 eligible women who received pre-pregnancy and pregnancy care in our hospital from January 2013 to June 2018 were included as study subjects. All pregnant women received pre-pregnancy care and prenatal care in our hospital for 3 months before and after pregnancy. Among them,1093 cases were screened for TORCH before pregnancy and early pregnancy,and 1025 cases were screened for TORCH only in the early stage of pregnancy. Among them,1093 cases received TORCH screening in pre-pregnancy and early pregnancy health care as the pre-pregnancy early pregnancy screening group,and 1025 cases received TORCH screening only in the early trimester of pregnancy as the early pregnancy screening group. The 826 women who delivered in our hospital at the same time but did not receive TORCH screening before pregnancy and early pregnancy were selected as the control group.Compared the detection results and management measures of two groups of maternal TORCH,and compared the maternal and infant pregnancy outcomes of the three groups.Results There was no significant difference in age,gestational age,number of births and delivery modes among the three groups(P>0.05). In the early pregnancy screening group,there were 102 cases of positive TORCH screening before pregnancy,with a positive rate of 9.33%. All of them adopted corresponding treatment measures to reexamine the pregnancy after negative; in the early pregnancy,there were 20 cases of positive TORCH screening,and 9 cases of pregnancy terminated after reexamination after treatment. A total of 106 TORCH positive cases were detected in the early pregnancy screening group,with a positive rate of 10.34%. Eight of them terminated their pregnancies according to the doctor's advice,and 98 continued their pregnancies under observation. Comparison of pregnancy outcomes among the three groups showed that the rate of adverse pregnancy in the control group was significantly higher than that in the pre-pregnancy and early pregnancy screening group,and that in the early pregnancy screening group was significantly higher than that in the pre-pregnancy and early pregnancy screening group(P<0.05).Conclusion TORCH screening in the early stage of pregnancy has high clinical value in improving the safety of pregnancy,effectively reducing the rate of adverse pregnancy outcomes and improving the level of prenatal and postnatal care.