Abstract: Objective To study the serum vitamin A and E in children with recurrent respiratory tract infection and normal children,and to provide clinical basis for disease prevention.Methods From April 2015 to April 2016,84 cases of children with recurrent respiratory tract infection diagnosed in the department of pediatrics of Beijing Fangshan maternal and child health hospital were selected,including 61 cases in the disease stage and 23 cases in the non-disease stage. 477 healthy children were examined at the early childhood development service center,including 232 with existing respiratory symptoms and 245 without illness. The subjects were divided into four groups according to whether they had repeated respiratory tract infection or not and whether they were in the disease stage. Result There was no significant difference in serum vitamin A level between different groups(P>0.05). The difference of serum vitamin E between different groups was statistically significant(P<0.05). Except that there was no statistically significant difference in Vitamin E level between groups 1 and 2,3 and 4,the differences in vitamin E levels between the other groups were statistically significant.(P<0.05). There were statistically significant differences in the distribution of VA and VE grades between different groups(P<0.05).Conclusions Serum vitamin A and E are associated with repeated respiratory tract infections.In order to prevent the occurrence of respiratory diseases,early prevention should be taken.