Abstract: Objective To investigate the status of death and disease burden among childbearing women in Binhu district for providing evidences in prevention and treatment of diseases.Methods The death data of women aged 15-49 years old in Binhu District from 2013 to 2017 were collected for retrospective analysis. The mortality rate, annual trend and years of life lost due to premature mortality (YLL) were calculated.Results The crude and adjusted mortality rates among childbearing women were 47.93 per 100 000 and 40.79 per 100 000, respectively. The mortality rate increased along with the increase of age (χ²= 77.548,P<0.001). Over the past five years, there was no significant trend of mortality rate among childbearing women (APC = 1.31%, 95%CI:-0.11-0.15, P>0.05), while suicide mortality showed an increasing trend (APC = 42.39%, 95%CI: 0.04-0.95, P<0.05).The years YLL of all causes of diseases was 7525. 06 years, and the standardized YLL rate was 1011.02 per 100 000.The burden of diseases were mainly composed of tumor, injury and poisoning and circulatory system diseases, accounting for 84. 85% of the total YLL.Conclusion The mortality rate of childbearing women in Binhu district was low. The disease burden of breast cancer, suicide, and heart disease were serious, which should be prevented and controlled in the future.