Abstract: Objective To analyze the application effect of PDCA principle in promoting the implementation of paediatric disease clinical pathway standard.Methods From January 2018 to May 2018, 699 cases with acute gastroenteritis, febrile convulsion and bronchopneumonia treated by continuously improved paediatric clinical pathway by PDCA were selected as the observation group. From July 2017 to December 2017, 624 cases with the above three diseases were selected as the control group. The clinical path entry rate, average hospitalization days, average hospitalization cost, antibiotic use days, drug ratio, discharge rate and patient satisfaction were compared, analyzed and evaluated between the two groups. Result After using PDCA circulation to manage clinical pathway, the average days of hospitalization, the average cost of hospitalization, the days of antibiotic use and the drug ratio in the observation group were significantly lower than those in the control group (P<0.05). The rate of clinical path entry and discharge according to the doctor's advice in the observation group was significantly higher than those in the control group (P<0.05).Conclusion Using PDCA principle to manage the clinical pathway, by strengthening the supervision of department managers, establishing a sound quality control system, strengthening the training of medical personnel on clinical pathway knowledge, perfecting the path system, and formulating effective reward and punishment system, can increase the rate of clinical path entry, shorten the hospitalization time, reduce the hospitalization cost, use antibiotics reasonably, reduce the drug ratio, standardize the physician's diagnosis and treatment behavior, make the diagnosis and treatment process of pediatric diseases more standardized, and improve the medical quality and patient satisfaction, It is worth popularizing and applying.