摘要:
目的 探讨小于胎龄儿(small for gestational age,SGA)与未成年期注意缺陷多动障碍(attention deficit hyperactive disorder,ADHD)发生的相关性。方法 计算机检索万方数据库、中国知网期刊全文数据库、维普中文科技期刊数据库等中文数据库及Pubmed、OVID、Cochrane databases等英文数据库,收集研究SGA在未成年期发生ADHD的队列研究或病例对照研究。经过文献筛选、资料提取和质量评价后,采用Stata 12.0软件进行Meta分析。结果 9篇文献满足纳入标准,Meta分析提示SGA在未成年期发生ADHD风险高于对照人群,OR值为1.63(95%CI:1.25,2.13)。亚组分析显示:未分型组临床研究Meta分析提示SGA在未成年期发生ADHD的风险高于对照人群,OR值为2.55(95%CI:1.42,4.56),注意力缺陷组和多动/冲动组临床研究Meta分析结果不支持SGA在未成年期发生ADHD的风险高于对照人群,OR值分别为1.34(95%CI:0.98,1.83)和1.27(95%CI:0.66,2.44)。结论 SGA可能会导未成年期ADHD发生的风险增加,但仍需高质量的临床研究进一步证实。
Abstract:
Objective To systematically review and meta-analyze the risk of small for gestational age (SGA) individuals to develop attention-deficit/hyperactivity disorder in childhood.Methods The cohort studies and case-control studies on the incidence of ADHD in underage SGA were searched in the Wan-fang database, CNKI, VIP, Pub Med and Cochrane databases, then the meta-analyses were conducted by using Stata 12.0 software based on the screened literature, the extracted data, and the evaluated methodological quality.Results In 9 studies, researchers showed that SGA subjects have a higher ADHD risk (OR: 1.63; 95%CI: 1.25-2.13). In subgroup analyses, studies relying on a categorical diagnosis showed SGA increased the risk of ADHD in childhood (OR: 2.55; 95%CI: 1.42-4. 56). We drew data from studies on ADHD symptomatology and found insignificant associations with inattention (OR: 1.34;95%CI: 0.98-1.83) and hyperactivity/impulsivity (OR: 1.27; 95%CI: 0.66-2.44) symptoms when compared with controls.Conclusion SGA subjects may have an increased risk of ADHD compared with controls, however, the results need further evaluation by high-quality clinical research.
百度学术
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