Abstract:
Objective To systematically evaluate the efficacy of lactobacillus in preventing hyperlipidemia in rodents.
Methods Based on Pubmed, Embase and other literature databases, a randomized controlled study on the prevention of hyperlipidemia in rodent by lactobacillus of various types that met the inclusion and exclusion criteria was searched until the end of June 2018 to extract effective data for online meta analysis.
Results Meta analysis of the preventive effect of lactobacillus on hyperlipidemia showed that the 95%
CI lines of L. casei (
RR=-56, 95%
CI =-1.1e + 02, -7), L. plantarum (
RR=-46, 95%
CI =-87, -25) and L. acidophilus (
RR=-41, 95%
CI =-67, -14) in the TC index forest map did not intersect with the invalid vertical line, and the others all intersect with the invalid line.
Conclusion Lactobacillus can prevent the formation of hyperlipidemia. L. rhamnous can significantly reduce TC and LDL level, and L. casei can significantly reduce TG and increase HDL level.