Abstract: Objective To analyze the interaction and relationship of SCH and PCOS.Methods 52 patients with SCH with PCOS and 55 patients with PCOS received treatment at our hospital from March, 2017 to February, 2018 were selected as the observe group and control group, respectively. The levels of biochemical markers, sex hormones and thyroid function indexes in two groups were compared. The relationship between serum TSH level and biochemical markers, sex hormones and thyroid function indexes levels in the SCH with PCOS patients was analyzed.Results The FPG, FINS, HOMA-IR, PRL, TSH levels in observe group were significantly higher than those in control group, and the LH, FSH, T levels were significantly lower than those in control group (P<0.05). The serum TSH level had positive correlation with P in the SCH with PCOS patients (P<0.01), and it had no significant correlation with other factors (P>0.05).Conclusion The SCH has a vital catalytic role in the metabolic disorder of PCOS, which increases the occurrence rate of abnormal pregnancy of PCOS patients.