Abstract: Objective To analyze the birth defects (BD) of perinatal children in Guangrao, Shandong in 2007-2016. To understand the situation of perinatal birth defects in guangrao county, Shandong province from 2007 to 2016.Methods The data of perinatal infants at least 28 gestation weeks, BD records and death records of children under 5 years old in Guangrao from 2007 to 2016 were collected to analyze the incidence and death of birth defects.Results The incidence of perinatal BD in Guangrao from 2007 to 2016 was 64. 86/10, 000 births, 63.62/10, 000 births, 80.35/10, 000 births, 89. 54/10, 000 births, 58.24/10, 000 births, 59. 51/10, 000 births, 84. 35/10, 000 births, 64. 85/10, 000 births, 43.16/10, 000 births, 48.72/10, 000 births, respectively, and with a total incidence of 64. 04/10, 000 births. The top three types of BD were polydactyly, congenital heart disease, and cleft lip and palate.BD accounted for 30.16% of deaths among children under 5 years old.Conclusion The incidence of BD in Guangrao was stable from 2007 to 2016. BD is the major cause of death among children under 5 years old. The prevention of congenital heart disease and cleft lip and palate should be reinforced in the future.