Abstract: Objective To investigate the epidemiological and clinical features of children with Mycoplasma pneumoniae pneumonia (MPP) in Shantou from 2014 to 2017.Methods A total of 823 children with respiratory infection admitted to our hospital from January 2014 to December 2017 were enrolled. The expression of serum Mycoplasma pneumoniae (MP) antibody was detected by passive agglutination. The clinical data of all children were collected. The epidemiological characteristics of children with Mycoplasma pneumoniae pneumonia in Shantou from 2014 to 2017 were analyzed.Results ① The MP positive detection rate of children was between 27.10% and 29.06%, with an average of 28.07% (231/823). There was no statistically significant difference in the MP positive rate in children during each year (χ²= 0.221, P=0.974> 0.05). ②The MP positive detection rate in winter was significantly higher than that in spring, summer and autumn (P<0.05). ③The MP positive detection rates in preschool children aged 3-6 years and children aged 6 years old were higher than <1 year old baby and 1-3 year old child, 3-6 years old preschool age child and> 6 years old school age (P<0.05). In terms of clinical symptoms, the incidence of wheezing and fixed dry and wet rales in infants was higher than that in preschool and school age groups. The incidence of extrapulmonary complications was higher in preschool and school age groups than that in the infant group (P<0.05). ④ There was no significant difference in the MP positive detection rate and clinical symptoms between male and female children (P>0.05).Conclusion The MP infection rate of a hospital in Shantou City is relatively high during the period of 2014-2017, which often occurs in preschool and school age children. The winter is the peak period of MPP, and the clinical symptoms of children will change according to the age of onset.