Abstract: Objective To explore the value of combined detection of serum PCT,IL-6,CRP and cervical secretion smear in the diagnosis of chorioamnionitis in pregnant women with premature rupture of membranes(PPROM).Methods 62 pregnant women with PPROM admitted to our hospital from March 2017 to December 2018 were selected as observation group,and 60 pregnant women with normal gestational weeks were selected as control group. In observation group,5 ml venous blood was taken within 12 hours of premature rupture of membranes(before using antibiotics) and during delivery. In control group,5 ml venous blood was taken during prenatal examination and delivery. All blood samples were processed. PCT,IL-6 and CRP levels and smear examination of cervical secretions were detected. Pathological specimens of the observation group were collected and the occurrence of chorioamnionitis was examined. Result The PCT,IL-6 and CRP levels in the peripheral blood of the observation group were significantly higher than those of the control group within 12 hours of premature rupture of membranes(P<0.05). Pathological examination showed that 39 pregnant women in the observation group suffered from chorioamnionitis. The concentration of PCT,IL-6 and CRP in periphery blood of patients with chorioamnionitis in the observation group were significantly higher than those of patients without chorioamnionitis within 12 hours of premature rupture of membranes(P<0.05). The sensitivity of L-6(92.30%) was significantly higher than that of PCT,CRP and cervical secretion smears. The positive predictive values of the four individuals were similar,and the specific and negative predictive values were all at a low level. When the combined detection was positive,the specificity,sensitivity,positive predictive value and negative predictive value were all at a high level,and the sensitivity and positive predictive value were the highest,both were 92.31%.Conclusion The joint detection of PCT,IL-6,CRP and cervical secretion smears is more effective than single detection in early prediction of chorioamnionitis in pregnant women with preterm premature rupture of membranes. It is a good method for evaluating the prognosis of PPROM mothers and infants.