Abstract: Objective To investigate and establish a health management model for infants of gestational diabetes mellitus(GDM)mothers,in order to promote the early detection and correction of abnormalities,and to ensure the health of infants of GDM mothers.Method A total of 100 GDM offspring and their main guardians were selected as the subjects in a cross-sectional study,and were divided into the experimental group and the control group. A health management model of weight and cognition was applied to the experimental group while the control group only received routine health care. The effectiveness of the health management model was evaluated by field measurement,questionnaires and blood indicators.Results There were no significant differences in length,weight,head circumference,body mass index(BMI) and the level of serum leptin between the experimental group and the control group(P>0.05). The development quotient(DQ) of all energy areas and the total DQ of the experimental group were significantly higher than those of the control group(P<0.05). There was no significant difference in the score of children with difficulties between two groups(P>0.05),but the significant differences were shown in other dimensions(P<0.05).Conclusion The health management model for infants of GDM mothers can better monitor physical growth and mental development of GDM infants,and correct the poor growth and development in time,which can reduce adverse effects of GDM on offspring.