Abstract: Objective To explore the clinical effect of endogerous and exogenous progesterone used to block the LH surge during ovarian stimulation for IVF/ICSI in normal ovarian responders who failed to get live birth in the cycles with conventional long protocol.Methods The data of 52 normal ovarian responders who failed to get live birth with conventional long protocol,and then were administrated with endogerous and exogenous progesterone used to block the LH surge during ovarian stimulation as a new protocol in our center from Sep. 2018 to Mar. 2019 were analyzed retrospectively. The duration and the total dosage of gonadotropin(Gn) used,the number of oocytes retrieved,the rate of M Ⅱ oocytes,fertilization and high quality embryos,the implantation rate,the clinical pregnancy rate and the live birth rate were compared between the two groups.Results The total dosage of Gn used (2079.81 ±534.08) U vs.(2716.82 ±825.09) Uwith progesterone used protocol were significantly less than those with conventional long protocol(P<0.05). Although the number of oocytes retrieved,the rate of MⅡ oocytes and the fertilization rate were not significantly different(P>0.05),the number of available embryos (2.82 ±1.91) vs.(1.49 ±1.42) was significantly increased in progesterone used protocol cycles(P<0.05). The number of high quality embryos and the rate were increased in progesterone used protocol cycles,but there was no significant difference between the two groups(P>0.05). The clinical pregnancy rate(45.00% vs. 14.29%),the implantation rate(34.38% vs. 8.47%) and the live birth rate(35.00% vs. 0.00%) were significantly improved in the FET cycles with progesterone used protocol(P<0.05).Conclusions The protocol that endogerous and exogenous progesterone used to block the LH surge during ovarian stimulation could provide better clinical outcomes for the patients with ovarian normal response but failed to get live birth with conventional long protocol in IVF/ICSI. It provides a new option for ovulation induction.