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高龄妊娠期糖尿病孕妇空腹血糖异常与体重增长对新生儿出生体重的影响

Effects of impaired fasting glucose and gestational weight gain of the elderly pregnant women with gestational diabetes mellituson on neonatal birth weight

  • 摘要: 目的 探讨35岁以上高龄妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇空腹血糖异常(impaired fasting glucose,IFG)与孕期体重增长(gestational weight gain,GWG)水平对新生儿出生体重的影响。方法 本研究为回顾性调查,以2017年1月1日-12月31日在电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院确诊为GDM且年龄≥35岁的853名符合纳入条件的孕妇作为研究对象,分别以IFG状态和GWG水平作为分层因素,比较新生儿出生体重的差异。结果 IFG孕妇巨大儿(macrosomia,MS)和大于胎龄儿(large-for-gestational age,LGA)出生率显著高于无IFG孕妇(MS:7.6%vs.3.4%; LGA:19.0%vs.8.2%,P<0.05)。GWG <10 kg孕妇的小于胎龄儿(small-for-gestational age,SGA)和低出生体重儿(low birth weight,LBW)出生率最高(分别为9.19%和8.65%,P均<0.05),而GWG≥15 kg孕妇MS和LGA出生率最高(分别为10.14%和19.53%,P均<0.05)。此外,仅在GWG≥15 kg、且存在IFG的孕妇LGA出生率最高(29.2%,P<0.05);存在IFG、且GWG <10 kg孕妇的LBW最高(10.0%,P=0.0399);无IFG、且GWG <10 kg孕妇的SGA最高(10.4%,P=0.0137)。结论 高龄妊娠期糖尿病孕妇GWG水平与IFG状态可影响新生儿出生体重,且两者可能存在相互作用。

     

    Abstract: Objective To explore the effects of impaired fasting glucose(IFG) and gestational weight gain(GWG) of the elderly pregnant women with gestational diabetes mellitus(GDM) on neonatal birth weight. Method A total of 853 elderly pregnant women(EPW) were recruited into this retrospective survey study from 1st January 2017 to 31st December 2017. The IFG status and GWG level were used as stratified factors and the difference of the delivery rate of newborns with abnormal birth weight was compared by the stratified factors.Results The birth rates of macrosomia(MS) and large for gestational-age(LGA) neonates from EPW with IFG status were significantly higher than those of EPW with non-IFG status(7.6% vs. 3.4% for MS and 19.0% vs. 8.2% for LGA,respectively,P<0.05). The birth rates of small for gestational-age(SGA) and low birth weight(LBW) neonates from EPW with GWG <10 Kg was the highest(9.19% and 8.65%,respectively,P<0.05) while the MS and LGA neonates from EPW with GWG≥15 kg group was the highest(10.14% and 19.53%,respectively,P<0.05). Moreover,the LGA rate was highest among EPW with GWG≥15 kg and IFG(29. 2%,P<0.05). The LBW rate was highest among EPW with IFG and GWG <10 kg(10.0%,P=0.0399). And the SGA rate was highest among EPW without IFG and with GWG <10 kg(10.4%,P=0.0137).Conclusion The level of GWG and IFG status among EPW with GDM may affect the occurrence of birth weight and they may interact with each other.

     

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