Abstract: Objective To explore the effect of vitamin AD on physical and neurological development of high risk children with cerebral palsy and the early intervention effect. Method The infants aged 0-12 months from April 2017 to October 2019 were selected for physical examination in our hospital the high risk group was selected according to the risk factors of premature delivery,low birth weight,asphyxia,hypoxic-ischemic encephalopathy and intracranial hemorrhage. The healthy infants of 0-12 months were selected as the group of healthy infants. The high-risk infants were divided into vitamin AD intervention group and control group according to the treatment intention of family members. After 3 months of treatment,the physical and neurodevelopmental assessment of high risk infants in different groups were compared.Results A total of 1500 infants were followed up,including 1000 high risk infants,500 healthy infants,561 high risk infants and 439 non-intervention infants There was no significant difference in the data of sex,mode of delivery,family economic level and high risk factors among different groups(P>0.05),and the content of serum vitamin AD in High Risk Group was lower than that in healthy group The developmental quotient(DQ) of physical and neurodevelopmental assessment was lower than that of healthy infants,and the developmental quotient(DQ) and physical development of high risk infants in nonintervention group were lower than that of intervention group(P<0.05).Conclusion The content of serum vitamin AD in high risk infants with cerebral palsy is lower than that in healthy infants. Sufficient dose of vitamin AD supplementation in early stage can improve the physical and neurological development of high risk infants.