Abstract: Objective Evaluation of the effect of prevention of mother-to-child transmission of syphilis in Wenshan Prefecture from2013 to 2017.Methods Based on the monthly report of the national management information system for the prevention of AIDS,syphilis and hepatitis B mother-to-child transmission and the relevant case information of pregnant women and children born with syphilis, the implementation and blocking effect of the intervention measures were analyzed.Result A total of 313407 pregnant women in Wenshan Prefecture were tested for syphilis in the past five years, of which 1479(0.47%) were infected with syphilis. The number of deliveries and live births was 1034 and 1043,respectively. In the past five years, the proportion of syphilis treatment increased from 93.92% to 100%, the proportion of standardized treatment increased from 37.57% to 74.57%, and the proportion of treatment for exposed children increased from 90.75% to 98. 22%. The incidence of congenital syphilis was 0.68% in the standardized treatment group, 3.38% in the unstandardized treatment group, and 6.25% in the untreated group(P=0.006). The proportion of pregnant women whose TRUST decreased or turned negative before delivery was 50.66% in the standardized treatment group, 12.50% in the unstandardized treatment group, and 17.64% in the untreated group(P<0.001). Incidence of preterm birth or low birth weight was 9.58% in in the standardized treatment group, 15.53% in the unstandardized treatment group, and 11.54%in the untreated group(P=0.019). The incidence of birth defects was 0.47% in the standardized treatment group, 0.27% in the unstandardized treatment group, and 3. 37% in the untreated group(P=0.044).Conclusion Wenshan Prefecture has achieved remarkable results in preventing mother-to-child transmission of syphilis, the standardized treatment rate of syphilis infection among pregnant women has increased year by year, and the incidence of congenital syphilis continues to decline.