Abstract: Objective To explore the correlation between serum D-dimer and blood lipid index in patients with preeclampsia.Methods From March 2018 to March 2019, 89 patients with preeclampsia who were treated in our hospital were selected as the study objects. According to the severity of preeclampsia, 45 cases of mild preeclampsia were classified as mild group, and 44 cases of severe preeclampsia were classified as severe group. A total of 69 healthy pregnant women who delivered in our hospital at the same time were selected as the control group. The serum D-dimer and blood lipid indexes of the three groups were compared.Results The levels of D-dimer, TG, TC and LDL-C in the mild and severe groups were significantly higher than those in the control group, and the levels of HDL-C were significantly lower than those in the control group. The level of serum D-dimer, TG, TC and LDL-C in the severe group were significantly higher than those in the mild group, while the level of HDL-C in the severe group was significantly lower than that in the mild group. The level of D-dimer was positively correlated with TG, TC and LDL-C(r= 0.631, 0.624, 0.581,P<0.05), and negatively correlated with HDL-C(r=-0.608,P<0.05).Conclusion The serum D-dimer of preeclampsia patients is higher, the degree of disease development is positively correlated with it. There is a certain correlation between serum D-dimer and blood lipid index, which has a certain reference value for the diagnosis of preeclampsia.