Abstract: Objective To analyze the prevalence of syndactyly during 2015 and 2018 in Guangdong province. Method Perinatal infants(28 weeks of pregnancy to 7 days after birth) and pregnant women delivered in 57 hospitals in Monitoring System of Birth Defects in Guangdong Province from 2015 to 2018 were selected as subjects. Descriptive analysis was used to analyze the distribution and type characteristics of syndactyly in Guangdong Province. Result A total of 1,147,063 medical records were anaylzed and the birth prevalence of Syndactyly was 13. 82/10,000 from 2015 to 2018. The rate of Syndactyly(fingers), Syndactyly(toes) and/10,000,0.38/10,000 and 9. 93 differen years was tested by chi-square trend test, and the difference was statistically significant(χ²= 12. 12,P< 0. 001). However,there was no statistically difference beween monthly incidences(χ²= 2. 08,P= 0. 15). The detection rate of simple syndactyly and syndactyly(toe) was relatively high in winter, and the detection rate was the highest in December. There was no significant difference in the detection rate of syndactyly(toe) among different age groups(χ²= 2. 21,P= 0. 69). There was significant difference in the detection rate of syndactyly(toe) between genders(χ²= 14. 33,P< 0. 01). The ratio of male/female was 1. 29. Conclusion It' s necessary to study the influencing factors of the increase in the detection rate of syndactyly(toe), to premote health education related to eugenics and birth defect prevention and control in order to reduce the occurrence of birth defects.