Abstract: Objective To explore the temporal and spatial distribution characteristics of syphilis-infected pregnant women and congenital syphilis children from 2013 to 2017, and to improve the effect of mother-to-child syphilis transmission blocking in Guizhou province. Method Adopting the management information system of mother-to-child transmission of HIV, syphilis and hepatitis B, to collect the information on syphilis-infected pregnant women and children born in Guizhou Province from 2013 to 2017, to do quantitative analysis on the incidence of syphilis infection in pregnant women and congenital syphilis. Result In the recent 5 years,2,483,224 pregnant women tested, within this group, the number of pregnant women reported positive of syphilis infection in Guizhou province was 9550, 143 cases were refer from Zhejiang, Yunnan and Guangdong Province. The syphilis positive rate from 2013 to 2017 in 5 cities of Guizhou were 5. 41‰ in Tongren City, 4. 90‰ in Liupanshui City, 4. 56‰ in Qiannan City, 3. 79‰ in Bijie city, and3. 66‰ in Anshun City respectively. These are relatively high-risk areas for pregnant women infected with syphilis. The positive number of maternal syphilis tests in the province showed an increasing trend year by year. There are 117 children of congenital syphilis born in pregnant women infected with syphilis. The number of children diagnosed with congenital syphilis increased gradually from 2013 to 2017 in province.Conclusion the trend in epidemics of maternal syphilis in the province would be estimated more exactly By exploring the temporal and spatial distribution characteristics of pregnant women infected with syphilis and the congenital syphilis cases,. By assessing the prevention and control effects of maternal and congenital syphilis, capital investment at all levels in the important areas and the measures of maternal and congenital syphilis prevention could be achieved. The blocking effect of mother-tochild syphilis transmission in Guizhou province would be further improved.