Abstract: Objective To understand the prevalence and characteristics of high-risk human papillomavirus(HPV) infection among women in Zhuanghe City, and to provide basis for making accurate prevention and control strategies for cervical cancer. Methods A cluster sampling method was used to select women who participated in cervical cancer screening and cervical HPV test in Zhuanghe for 2014—2019 years. The subjects were 35-64 year old rural women who had sex life history or mobile women living in Zhuanghe for more than half a year. Joinpoint regression program software was used to calculate annual change percentage(APC) and trend test. Results A total of 30 487 cases were detected from 2014 to 2019, and 3 265 cases were HR-HPV positive,with a positive rate of 10. 71%, of which the infection rate of HPV16/18 was 2. 60%, and that of other types was 8. 11%; the infection rate of HRHPV increased from 9. 37% in the age group of 40-44 to 12. 58% in the age group of 60-64, with significant difference(χ²=27. 125,P< 0. 05); HPV positive rate increased at an average rate of 5. 1% per year(t= 2. 90,P< 0. 05), HPV16/18 infection rate increased at an annual rate of 1. 2%(-3. 9%-6. 7%), the difference was not statistically significant(t= 0. 6,P= 0. 6); HPV infection rate of other types increased at an annual rate of 6. 4%(0. 0%-13. 1%)(t= 2. 8,P< 0. 05). Conclusion The infection rate of HR-HPV in Zhuanghe city increased along with age increased and increased year by year, and the increasing HR-HPV type was mainly non-16/18 type. The prevention and control strategy of cervical cancer should be formulated according to local conditions to reduce HR-HPV infection and ultimately achieve the goal of reducing the incidence of cervical cancer.