Abstract: Objective To summarize the clinical characteristics and growth and development of neonates with cow's milk protein allergies(CMPA) within one years old. Methods 60 CMPA children within 28 days from March 2019 to September 2019 in Nanning No. 8 people's Hospital and other hospitals conducted prospective analysis their growth, routine blood test, total Ig E, blood vitamin A(VitA), 25-hydroxy-vitamin D(25-OH-VitD), the change of serum zinc concentration and prognosis were observed. Results Among the 60 babies, skin rash were the main symptoms, and the others are the average age of onset was(14. 67 ± 5. 17) days, and the clinical symptoms changed after use pure breast-feeding or low-sensitivity milk powder,the result from 1 year follow-up study showed that, 26 cases were tolerated, the average time of toleration was(9. 61 ± 1. 18) months, the total Ig E increased in 12 cases in the neonatal period, only one case developed immune tolerance before the age of one year, the body length, weight growth rate, blood 25-hydroxy-vitamin D and blood zinc concentration were lower than those of non CMPA children, and the incidence of anorexia, map tongue, pillow baldness, finger desquamate, recurrent respiratory infection and bronchial asthma were higher than those of non CMPA children. Conclusion With rash as the main clinical manifestation, followed by digestive tract symptoms. The overall prognosis of CMPA was relatively good, but the immune tolerance time of patients with increased total Ig E was prolonged, which can be considered as one of the prognostic factors of evaluation. CMPA had an effect on the growth and development of infants and the absorption of 25-hydroxy-vitamin D and zinc.