Abstract: Objective To analyze comprehensive perinatal empowerment intervention on the effect of breastfeeding. Methods 388 pregnant women in our hospital from June 2019 to December 2020 were recruited as intervention group. They were provided with breastfeeding guidance,empowerment health education and breast health care. 385 pregnant women during the same period were recruited as control group. The differences of awareness of breastfeeding and pure breast feeding rate were compared between the two groups. Results At the baseline study,the percentage for the right answer of adhering exclusive breastfeeding for 6 months was 93. 81%(364/388) in the intervention group and 92. 46%(356/385) in the control group. The average scores of questions about breastfeeding skill and strategies dealing with problems during breastfeeding were (58. 76 ± 16. 39)(intervention group) vs (58. 09 ±16. 09)(control group) respectively. After intervention,the average score was (95. 28 ± 7. 09) in the intervention group and (70. 13 ±12. 38) in the control group (P< 0. 05). The percentage of pure breastfeeding in the intervention group was 85. 82% (333/388),which was significantly higher than 80. 26% (309/385) in the control group at 6 months postpartum (P< 0. 05). Conclusion Comprehensive perinatal empowerment intervention could improve pregnant women's awareness of breastfeeding and increase the rate of postpartum pure breast feeding within 6 months.