Abstract: ObjectiveTo analyze treatment of maternal syphilis infections and factors related to it in Qingdao.MethodsCasereporting records of maternal syphilis data in 2015-2019 were collected from national information system of prevention of mother-tochild transmission(MTCT) of HIV, syphilis and hepatitis B virus. Treatment of maternal syphilis infections and factors in relation to it were analyzed.ResultsTotally 1 387 maternal syphilis were recruited for analysis, and the rate of treatment was 69. 0%. The rate of treatment increased from 2015-2019, and the difference was significantly(P< 0. 05). Logistic regression showed that pluripara who have given birth≥2 were less likely to receive syphilis treatment(OR= 0. 561, 95%CI:0. 357-0. 880,P= 0. 012) compared to primipara. Infection status unknown of husband/sexual partner was risk factors for not receiving syphilis treatment(OR=0. 381, 95%CI:0. 264-0. 551,P< 0. 001). Being diagnosed in late pregnancy was risk factors for not receiving syphilis treatment(OR=0.171, 95%CI:0. 115-0. 255,P< 0. 001). The probability of receive syphilis treatment among maternal syphilis stage Ⅰ-Ⅲ patients was 1. 605 times compared with patients who were latent syphilis(95%CI:1. 031-2. 500,P= 0. 036). Pregnant women with nontreponemal serological tests titer ≥1∶ 8 were more likely to receive treatment(OR= 1. 801, 95%CI:1. 225-2. 649,P= 0. 003).ConclusionThe treatment rate of maternal syphilis infection was reletively low in Qingao. The number of childbirths, syphilis infection status of husband/sexual partner, period being diagnosed, clinical stage of maternal syphilis, nontreponemal serological test titer level are influence factors in relation to treatment. Specific measures should be taken to increase the rate of treatment.