Abstract: ObjectiveTo analyze the status and effect of prevention of mother-to-child transmission of hepatitis B in Baoan District, Shenzhen from 2018 to 2020.MethodsHepatitis B surface antigen(HBsAg)-positive mothers who gave birth from 2018 to 2020 and their live newborns in Baoan District were recruited in study. Detection and treatment of HBsAg-positive mothers, follow-up and post-vaccination serological test for hepatitis B virus(HBV)-exposed children were analyzed in this research.ResultsThe total number of pregnant women in Baoan District from 2018 to 2020 were 139 980. The rate of HBsAg testing during pregnancy increased from 98. 31% in 2018 to 98. 90% in 2020. The rate of HBV DNA detection and antiviral therapy with high viral load increased from 49. 59% and 28. 68% in 2018 to 91. 94% and 83. 98% in 2020, respectively(P< 0. 05). The average rate of 1^st dose hepatitis B vaccine and hepatitis B immunoglobulin(HBIG) coverage of HBV-exposed newborns were 99. 98% and 99. 94% from 2018 to 2020. A total of 7 291 infants(84. 64%) finished follow-up out of 8 614 HBV-exposed children born from 2018 to 2019, among which 7 250(99. 44%) had completed three doses hepatitis B vaccine. 3 658 had received post-vaccination serological test(50. 17%) and 10 had been tested as HBsAg-positive, the rate of mother-to-child transmission of HBV was 0. 27%(10/3 658). 3 633 children exposed to HBV born in 2020 is still in follow up progress, and relevant data can only be analyzed after all cases are closed.ConclusionMeasures to prevention of mother-to-child transmission of hepatitis B such as HBsAg screening and combined immunization in Baoan District are well implemented, while innovative service models and strategies are still need to increase the proportion of post-vaccination serological test among HBV-exposed children.