Abstract: ObjectiveTo explore the factors in relation to depression in early pregnancy.MethodsTotally 200 pregnant women with depression and 200 healthy pregnant women were recruited during early pregnancy at Nanjing Maternity and Child Health Care Hospital from June 2019 to June 2020 through a case-control study. Binary logistic regression was used to analyze the factors in relation to depression in early pregnancy, including the age of pregnant women, pre-pregnancy working status, educational background, living conditions, annual per capita household income, unplanned pregnancy, history of abortion, primary parturient, and history of artificial assisted reproduction.ResultsLiving conditions, unplanned pregnancy and annual per capita household income might affect early pregnancy depression. Couple living together(OR= 0. 524,P= 0. 004, 95%CI:0. 338-0. 813), unplanned pregnancy(OR= 2. 068,P= 0. 002,95%CI:1. 312-3. 260), high-income or middle-income pregnant women(OR= 2. 633,P= 0. 004,95%CI:1. 370-5. 061;OR= 2. 362,P= 0. 005,95%CI:1. 294-4. 310) were the influencing factors of early pregnancy depression.ConclusionCouple living together, adequate family and social support, and avoiding unplanned pregnancy may be beneficial to reduce depression in early pregnancy.