Objective To provide evidence for effective development of human papilloma virus (HPV) vaccine consultation service.

Methods A total of 450 clients at HPV vaccine consultation clinic were recruited as study subjects in Nanjing Maternal and Child Health Hospital, Jiangsu Province. Their general information, question of consultation and medical advice received were analyzed.

Results Their age ranged from 20 to 45 years old, accounting for 93.69%; 97.56% consultants had sexual experience and about 17.56% of them had HPV infection and cervical-related lesions. They mainly focused on information related to vaccination, accounting for 78.89%. The next was related to vaccination under HPV infection, accounting for 17.56%.Of which, 91.78% consultants were suggested to receive HPV vaccine, 6.89% were postponed, and 1.33% were not appropriate for vaccination.

Conclusion It is necessary to set up an HPV vaccine consultation clinic to promote rational vaccination. Meanwhile, professional consulting team should be established, standardized consultation service should be provided, and information system should be strengthened to improve vaccination service quality and explore the long-term protective effect on local population.