Abstract: Objective To analyze the therapeutic induced laborof birth defects between 2011 and 2016 in Guangdong province.Method The study involved birth defects monitor records of mothers and infants between 2011 and 2016 from 58 monitoring network hospitals in Guangdong province. Descriptive statistics method was used to analyze the distribution characteristic of the infants who received therapeutic induced labor for birth defects. Result There were 51 574 cases of birth defects. Among them, 14 264 mothers with birth defect infant received therapeutic induced labor, accounting for 27. 66%. Among 14264 mothers, 9575 cases (67. 22%) received therapeutic induced labor at their gestational age < 28 weeks. 4689 mothers (32. 87%) received therapeutic induced labor at their gestational ages ≥ 28 weeks. The number of male fetuses whose mother received therapeutic induced labor was more than that of female fetuses. The sex ratio was 1. 46. There was a statistical difference in the gender of birth defect infants (χ²=2471. 81, P <0. 001). The trend test analysis showed that from 2011 to 2016, the therapeutic induced labor rates of the birth defects had a decreased trend (χ²=262. 91, P<0. 001). Among the mothers who received therapeutic induced labor at their gestational age < 28 weeks, 92. 52% of their infants were male and 93. 33% were female. Among the mothers who received therapeutic induced labor at their gestational age ≥ 28 weeks, 9. 79% of their infants were male and 13. 55% were female. Whether the mothers with birth defects to applied therapeutic induced labor was related to the mothers' age, cultural level, family income, delivery times, pregnant times, infant gender, gestational age and the monitor year. During 2011-2016, most of the birth defects were diagnosed by ultrasound (77. 99%), however, the rates of ultrasonography showed a downward trend, and the rates of chromosome diagnosis emerged an upward trend.Conclusions The gestational age of the mothers with birth defect infants when they received therapeutic induced labor was advanced in Guangdong. Whether to choose therapeutic induced labor was affected by non-medical determinants. Diagnostic methods of birth defects show diversification.