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刘媛玲, 黄晓芬, 陈彩香, 黄平, 聂石婵. 对比分析CA125、HE4在正常孕妇及妊娠合并盆腔包块孕妇体内的表达情况[J]. 中国妇幼卫生杂志, 2017, 8(3): 34-36,44.
引用本文: 刘媛玲, 黄晓芬, 陈彩香, 黄平, 聂石婵. 对比分析CA125、HE4在正常孕妇及妊娠合并盆腔包块孕妇体内的表达情况[J]. 中国妇幼卫生杂志, 2017, 8(3): 34-36,44.
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LIU Yuan-ling, HUANG Xiao-fen, CHEN Cai-xiang, HUANG Ping, NIE Shi-chan. Comparison the expressions of CA125 and HE4 in normal pregnant women and pregnant women with pelvic mass[J]. CHINESE JOURNAL OF WOMEN AND CHILDREN HEALTH, 2017, 8(3): 34-36,44.
Citation: LIU Yuan-ling, HUANG Xiao-fen, CHEN Cai-xiang, HUANG Ping, NIE Shi-chan. Comparison the expressions of CA125 and HE4 in normal pregnant women and pregnant women with pelvic mass[J]. CHINESE JOURNAL OF WOMEN AND CHILDREN HEALTH, 2017, 8(3): 34-36,44.
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对比分析CA125、HE4在正常孕妇及妊娠合并盆腔包块孕妇体内的表达情况

Comparison the expressions of CA125 and HE4 in normal pregnant women and pregnant women with pelvic mass

    摘要
  • 摘要: 目的 探讨CA125、HE4在正常孕妇及妊娠合并盆腔包块孕妇体内的表达关系,为卵巢恶性肿瘤的早期诊断提供依据。方法 选取深圳市宝安区松岗人民医院2014年5月-2016年5月在该院进行包块检查并手术治疗的妊娠合并盆腔包块孕妇80例(B组),以及健康孕妇80例(A组)作为随访主体。所有入选的孕妇于不同孕期(早孕12周以前、中孕12~28周、晚孕29周后)测定CA125、HE4在不同孕期的表达水平。80例妊娠合并盆腔包块孕妇经病理检测有恶性卵巢癌5例、交界性肿瘤4例、良性卵巢疾病71例。探讨妊娠合并盆腔包块的孕妇血清HE4、CA125变化,对判断盆腔包块良(恶)性的作用。结果 健康孕妇体内HE4的浓度于早、中、晚孕期差异无统计学意义(P>0.05);健康孕妇体内CA125的浓度于早、中、晚孕期稍有升高,但差异无统计学意义(P>0.05);盆腔包块孕妇体内CA125及HE4的浓度均明显高于同期健康孕妇体内水平(P<0.05);恶性卵巢癌患者体内CA125及HE4的浓度均明显高于良性卵巢疾病(P<0.05);恶性卵巢癌患者体内CA125及HE4的浓度均明显高于同期健康孕妇体内水平(P<0.05);良性卵巢癌患者体内CA125及HE4的浓度均略高于同期健康孕妇体内水平(P>0.05),但仍在正常范围之内。结论 恶性卵巢癌孕妇体内CA125及HE4的水平较卵巢疾病及健康孕妇高,提示CA125及HE4可作为恶性卵巢癌的生物标志物。

     

    Abstract: Objective To investigate the expression of HE4 and CA125 in normal pregnant women and pregnant women with pelvic mass,and to provide evidence for early diagnosis of ovarian malignant tumors.Methods From May 2014 to May 2016,80 pregnant women (group B) with pelvic mass examined and operated and 80 healthy pregnant women (group A) examined in Songgang People's Hospital of Bao'an district were selected and followed-up.The expression levels of HE4 and CA125 of all the pregnant women in different pregnancy stage (12 weeks ago,12-28 weeks,29 weeks later) were detected.Among the 80 pregnant women complicated with pelvic mass,the pathological examination showed that there were 5 cases of malignant ovarian cancer,4 cases of borderline tumor and 71 cases of benign ovarian disease.The changes of serum HE4 and CA125 in pregnant women with pelvic mass were investigated and estimated their effect on diagnosing benign and malignant pelvic masses.Results The difference of HE4 concentration in healthy pregnant women in early,middle and late pregnancy was not statistically significant (P>0.05).But the concentration of CA125 in healthy pregnant women was slightly increased in the early,middle and late pregnancy,the difference was not statistically significant (P>0.05).The concentrations of CA125 and HE4 in pregnant women with pelvic masses were higher than those in the healthy pregnant women (P<0.05).The concentrations of CA125 and HE4 in the patients with malignant ovarian cancer were higher than those in pregnant women with the benign ovarian disease (P<0.05).The concentrations of CA125 and HE4 in patients with malignant ovarian cancer were higher than those in healthy pregnant women (P<0.05).The concentrations of CA125 and HE4 in patients with benign ovarian cancer were slightly higher than those in healthy pregnant women (P>0.05),but the different was still in the normal range.Conclusion The levels of CA125 and HE4 in ovarian cancer patients were higher than those in patients with benign ovarian disease and health pregnancy,CA125 and HE4 could be used as biomarkers for malignant ovarian cancer

     

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