Abstract: Objective To explore the association between Interferon Regulatory Factor-6 (IRF-6) G820 A polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCL/P) susceptibility.Methods Literature searches of CNKI, CBM, Wan Fang, Pub Med, Medline and Science Direct database were conducted to identify the related case-control studies. Statistical analyses were conducted by the Rev Man 5. 3 software.Results A total of 15 articles involving 7470 study subjects were finally included in the Meta analysis. Meta analysis results showed that the risks of having NSCL/P among Asian and American population with G allele were higher than those with A allele (for G vs A:OR=1. 53, 95% CI 1. 40-1. 68; GG vs GA:OR=1. 67, 95% CI 1. 47-1. 90; GG vs AA:OR=2. 02, 95% CI 1. 64-2. 49; GG vs GA + AA:OR=1. 74, 95% CI 1. 54-1. 96; GG + GA vs AA:OR=1. 61, 95% CI 1. 33-1. 96). There were statistical significances.Conclusions IRF-6 gene G820 A polymorphism could be considered as a risk factor for NSCL/P among Asian and American population.