Abstract: Objective To explore the correlation between vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and preeclampsia.Methods From January 2013 to November 2016, 100 pregnant women who were diagnosed preeclampsia in Wujin People Hospital were enrolled in the study, and 49 pregnant women were severe preeclampsia, 51 pregnant women were mild preeclampsia. At the same time, 50 healthy pregnant women were enrolled as control group. The levels of VEGF and MMP-9 in placenta were detected by Western blotting and RT-PCR. The levels of VEGF and MMP-9 in serum and urine were measured by enzyme-linked immunosorbent assay (ELISA).Results Western blotting and RT-PCR showed that the expression levels of VEGF and MMP-9 in placenta of pregnant women with mild and severe preeclampsia were lower than those in control group, and the difference was statistically significant (P< 0. 05). The levels of VEGF and MMP-9 in the serum and urine in pregnant women with mild and severe preeclampsia than those in control group, and the difference was statistically significant (P< 0. 05).Conclusion VEGF and MMP-9 are involved in the pathophysiological changes of preeclampsia and are closely related to the occurrence and severity of preeclampsia.