Abstract: Objective To investigate the correlation between genes related sites distribution of folic acid metabolism disorder and fetal growth retardation (FGR) in Foshan.Methods From August 2014 to August 2016,1500 pregnancy women examined in Foshan maternal and child health hospital.Among the pregnant women who was confirmed FGR,100 pregnant women were selected as study group,and 100 normal pregnant women were selected as control group according to the age,gestational age,household registration information in study group.The pregnant women in two groups were monitored homocysteine level and serum folate levels from 5-8 gestational weeks,and the pregnant women with folic acid metabolism disorder were detected folic acid metabolism gene polymorphism.Results(1) Compared with the control group,the levels of Hcy in plasma of TT,CC and GG genotypes in C677 T,A1298C and A66 G were significantly higher than those in control group (P<0.05).The total mutation frequency of T,C and G allele were significantly higher than those in control group (P<0.05).(2) Compared with CC type in C677 T,the incidence rate of CT,TT and CT+TT type increased the morbidity of folate metabolism (P<0.05);Compared with AA type in A1298 C,the incidence rate of AC,CC and AC+CC type increased the morbidity of folate metabolism (P<0.05);Compared with AA type in A66 G,the incidence rate of AG,GG and AG+GG type increased the morbidity of folate metabolism (P<0.05).Conclusion The genotypes distribution of folate metabolism was related to FGR in early pregnant women in Foshan area.