Abstract: Objective To explore the level of pancreatic stone protein (PSP/reg) in children with sepsis and its significance.Methods 92 cases of sepsis in PICU from February 2016 to December 2017 were selected, including 38 severe sepsis children (severe sepsis group), 54 sepsis children (sepsis group). 60 children without sepsis were selected as the control group. The level of plasma PSP/reg was detected in each group.Results In the severe sepsis group, the plasma PSP/reg on the first day, the third day and the seventh day was 87. 05 (63. 23, 118. 50) ng/ml, 89. 01 (57. 10, 120. 43) ng/ml and 52. 18 (32. 10, 94. 52) ng/ml, respectively. They were significantly higher than those in control group and sepsis group (P<0. 05). The plasma PSP/reg on the first day, the third day and the seventh day in the death group was 84. 82 (70. 11, 123. 10) ng/ml, 110. 03 (67. 39, 172. 04) ng/ml and 114. 02 (89. 02, 160. 51) ng/ml, respectively. They were significantly higher than those in the surviving children (P<0. 05). The plasma PSP/reg on the first day, the third day and the seventh day in children with more than 2 organs failure were 78. 92 (61. 70, 105. 92) ng/ml, 102. 38 (70. 15, 142. 16) ng/ml and 94. 02 L (81. 43, 132. 02) ng/ml, respectively. They were significantly higher than those of children with less than one organ failure (P<0. 05). The area of the ROC curve for plasma PSP/reg judging the prognosis of children with sepsis was 0. 857 (P<0. 05). Cut-off value was 60. 80 ng/ml. The sensitivity and specificity of judging the death of the children were 93. 80% and 68. 42%, respectively.Conclusion The level of plasma PSP/reg in children with sepsis is significantly higher, which has a certain relationship with the severity and prognosis of the children. It has a high clinical value.