Abstract: Objective To investigate the measures and clinical effect of systematic early intervention on high risk infants.Methods A total of 301 high risk infants, who were treated and recovered in our hospital between 2012 and 2013, were dived into invention group (156) and non-interventiongroup (145) according to the willingness of their parents. Meanwhile, 160 healthy children who received the routine 1 month physical examinations were selected as control group. All of the cases were measured using Gesell developmental scale when they were one year old. The outcomes and intelligence developments of the high risk infants were compared before and after the systematic management. Result The adaptability, gross motor, fine motor, language and individual social in the intervention group were significantly higher than those of the non-intervention group. However, the incidence of sequla in the intervention group was significantly lower than that in non-intervention group.Conclusions Systematic early intervention, follow-up and brain rehabilitation treatment can promote the intelligence development of high-risk infants and motor development, reduce the incidence of sequelae of nervous system, improve the quality of the patient's survival. Family-centered early intervention is a simple method and it is easy to be accepted.