Abstract: Objective To explore the effect of postpartum management on glycemic controlling of gestational diabetes mellitus patients.Methods During March 2014 to March 2016, 386 gestational diabetes mellitus (GDM) patients who were cured in Shenzhen maternal and child health care hospital were selected randomly as subjects, and they were divided into two groups according to the random number table, each group with 193 cases. The patients in control group were received routine discharge guidance; the patients in observation group were applied postpartum management basing on the routine discharge guidance. The glycemic level was compared after postpartum 3 d, 42 d and 90 d between the two groups, and compared the disease knowledge of the two groups before and after postpartum 3 month. Result Compared with control group, research group had lower level in fasting blood-glucose, 2-hour postprandial blood glucose and glycosylated hemoglobin after postpartum 30 d and 90 d, and the differences were statistically significant (P< 0. 05). After intervention, research group had higher score of GDM health knowledge than control and before the intervention (P< 0. 05). After postpartum 3 month, research group had lower BMI reduce than that in control group, and the difference was statistically significant (P< 0. 05).Conclusion Postpartum management can improve postpartum glycemic controlling of GDM patients, and this method is suitable for clinical application and generalize.