Abstract: Objective To compare the clinical effect and cost-effectiveness of antagonist and microstimulation protocol among elderly infertile patients with low ovarian reserve function.Methods A Retrospective analysis of 60 patients aged over 35 years old who received in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) -embryo transfer (ET) was conducted at the Reproductive Center of Yinchuan Maternal and Child Health-Care Center from October 2015 to October 2017. According to different controlled ovulation promotion protocol, thepatients were divided into antagonist group (first group, 30 cases) and microstimulation group (second group, 30 cases). The clinical effect and cost-effectiveness ratio of the two groups were compared.Results ① Both the cumulative clinical pregnancy rate and cumulative live rate in the first group were higher than those in the second group. There was a statistical difference between the two groups (P< 0.05). ② The cost of getting each mature egg, one quality embryo and one live birth in the first group were less than those in the second group. There was a statistical difference between the two groups (P< 0.05).Conclusion Comprehensive analysis showed that the antagonist regimen was an ideal choice in elderly infertility patients with low ovarian reserve function both in terms of clinical effect and health economics.