Abstract: Objective To explore the application of transvaginal color doppler ultrasound in conservative treatment of ectopic pregnancy.Methods From December 2015 to December 2016, a total of 58 ectopic pregnancy patients were recruited from Hunan provincial maternal and children's health care hospital.All of these patients were treated by conservative approach.At the same time, the process of the conservative treatment of the patients was dynamically observed by using the transvaginal color doppler ultrasound.All of the clinical data of the patients were analyzed retrospectively.The contents of the statistical analysis included the results of conservative treatment, the relationship between the pelvic cavity accumulates liquid, blood flow signal, types and size of masses, blood human chorionic gonadotropin (HCG) and effect of therapy.Moreover, the application value of transvaginal color doppler ultrasound in conservative treatment of ectopic pregnancy was summarized.Results Of 58 patients treated by conservative approach, 40 cases was treated successfully.The treatment success rate was 68.97%.The other 18 cases were treated by surgery after failure of conservative treatment.There was statistical difference in pelvic cavity accumulates liquid, blood flow signal, types and size of masses, blood HCG between the success group and the failure group (P<0.05).Conclusions The application of transvaginal color doppler ultrasound in conservative treatment of ectopic pregnancy can improve the evaluation results of patients curative effect.It has important clinical value in both helping to decide the treatment protocol and improving the effect of therapy.