Abstract: Objective To observe the body fluid and cellular immune function of children with cerebral palsy.Methods A total of 42 cases of children with cerebral palsy who received rehabilitation in our hospital from March 2017 to March 2018 and 50 normal children were selected as the subjects. T lymphocyte subsets levels and humoral immune indicators of the subjects were tested by flow cytometry and immunoturbidimetry. Immune indexes of body fluid and cell of different severity of children with cerebral palsy were compared by the gross motor function test scale-88 (GMFM-88) score. Result There was no significant difference in T lymphocyte subsets between normal children and children with cerebral palsy (P> 0.05). Humoral immunity index of children with cerebral palsy was significantly lower than that of normal children (P< 0.01). The difference in humoral immunity among children with different severity of cerebral palsy was statistically significant (P< 0.05). The more serious the child's condition was, the more serious the humoral immune deficiency was.Conclusions Children with cerebral palsy have humoral immune deficiency. The more serious the child's condition was, the more serious the humoral immune deficiency was. There was no significant difference in cellular immunity between children with cerebral palsy and normal children.