Abstract: Objective To analyze the epidemic characteristics of hand, foot and mouth disease (HFMD) outbreaks from 2011 to 2017 in Hongta District of Yuxi City, so as to provide evidence for further targeted measures.Methods The retrospective epidemiological survey methods was used.Results The data showed that from 2011 to 2017 a total of 13 HFMD emergencies occurred in Hongta district. The number of patients was 213 and the attacked rate was 3.8% (213/5596). The most reported patients were children. It accounted for 77.9%. The highest occurrence number was in 2012, it accounted for 46.2%. The median incidence of emergency was 3.2%. Emergencies occurred frequently in the second quarter and the fourth quarter. the incidence of emergency in the fourth quarter (9.3%) was significantly higher than that in the second quarter (2.4%) (P< 0.05). Central city streets reported the most emergencies. The incidence of emergencies in urban kindergartens was higher than that in rural kindergartens (P< 0.01). Most of the emergencies firstly started in the youngest children. Most of the infections were confirmed as EV71 virus infection. There was no significant correlation between the time interval of start-meet the emergency standard and the time interval of the first and last cases.Conclusions It is necessary to pay attention to the occurrence of HFMD emergencies during the rising period of epidemic season of HFMD. The targeted measures should be taken according to the epidemiological characteristics and the complexity of the outbreak factors.