Abstract: Objective To study the expression change and clinical value of tumor suppressor gene XAF1 in cervical cancer tissue.Methods A total of 200 cases of cervical tissue specimens in our hospital from January, 2014 to December, 2016 were selected as the research object. The expression of XAF1 in normal cervical epithelium, cervical intraepithelial neoplasia (grade Ⅰ and Ⅲ) and cervical squamous cell carcinoma (stage Ⅰ to Ⅲ) was analyzed by paraffin section. The proportions of XAF1 positive cells in different specimens were counted.Results The expression of XAF1 was higher in normal cervical epithelial tissue, and the proportion of positive cells was 92.86%. With the increase of the degree of cervical carcinogenesis, the expression of XAF1 was gradually weakened (P< 0.05). The proportion of XAF1 positive cells in stage Ⅰ-Ⅱ cervical squamous cell carcinoma was 11.11%. The proportion of XAF1 positive cells in stage Ⅲ-ⅠV cervical squamous cell carcinoma was 21.74%, and there was no statistical significance between the two groups (P> 0.05).Conclusion The expression of XAF1 in cervical carcinomatous tissues and cervical cancer tissues are significantly decreased. Promoting its expression may play a role in inhibiting the occurrence and development of cervical cancer.