Study on the relationship between growth hormone、insulin-like growth factor 1 and breast cancer
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摘要: 目的 通过了解乳腺癌患者的生长激素、胰岛素样生长因子-1水平,探讨胰岛素样生长因子-1与乳腺癌的关系。方法 采用病例对照研究,以年龄进行1:1配比乳腺癌患者和对照组各197例,分析两组一般情况、生长激素、胰岛素样生长因子-1水平与乳腺癌发生的关系。结果 生长激素水平比较差异无统计学意义(P>0.05);50岁以下女性胰岛素样生长因子-1病例组与对照组比较差异有统计学意义(P<0.01),50岁以上组比较差异无统计学意义(P>0.01);用1:1匹配条件Logistic回归分析显示,β=0.137,OR=1.147(P<0.01)。结论 胰岛素样生长因子-1水平增高是乳腺癌的危险因素,可作为乳腺癌筛查的指标之一。
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关键词:
- 乳腺癌 /
- 危险因素 /
- 胰岛素样生长因子-1
Abstract: Objective To explore the relationship between insulin-like growth factor 1 and breast cancer by understanding the level of human Growth Hormone and insulin like growth factor 1 (IGF 1) of breast cancer patients.Methods A 1:1 age matched case-control study was used.In all, 197 breast cancer patients and 197 control women were collected.The general information, growth hormone, and insulin-like growth factor 1 levels of the two groups were analyzed.Results There was no statistically significant difference in the growth hormone levels between the two groups (P>0.05).There was a statistically significant difference in the insulin-like growth factor 1 of women under 50 years old between the breast patients and the control group (P<0.01), and there was no statistically significant difference in that of women over 50 years old between the two groups (P>0.01).The results of Logistic regression analysis showed that β=0.137, OR=1.147 (P<0.01).Conclusion The higher level of insulin-like growth factor 1 is a risk factor for breast cancer.It may be used as one of the indicators of breast cancer screening.-
Keywords:
- breast cancer /
- risk factors /
- insulin-like growth factor 1
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