Abstract: Objective To understand the status of high-risk pregnancy under "two-child policy", and in order to provide reference basis for high-risk pregnancy management in the current situation of lacking obstetrics resources.Methods Descriptive statistics, One-Way ANOVA and Chi-squared test were used to analyze antenatal examination data between 2015 and 2016 derived from maternal and child information system of Guang Dong province.Results The incidence of high-risk pregnancy was 39. 15% in 2016, which grew by 14 percent than 2015, while the incidence of severe high-risk pregnancy was 30. 67%, and the incidence of ordinary high-risk pregnancy was 8. 48%. High-risk pregnancy distributed mainly in the second trimester. The top three factors of severe high-risk pregnancy were scar uterus, abnormal obstetric and multifetation. The top three factors of ordinary high-risk pregnancy were mother's age < 18 years old or age ≥ 35 years old, embryo transplantation, abortion more than 3 times.Conclusion It is need to strengthen the consciousness of women's health care; improve the rate of regular antenatal care, particularly on early trimester; screening high-risk pregnant women early; focus on the factors of scar pregnancy, aged, abnormal obstetric and complications of pregnancy. And to ensure mother-infant safe, so as to reduce adverse pregnancy outcome and escort the two-child policy.