不同孕期D-二聚体参考区间的建立及临床意义分析

Development of the reference intervals for D-dimer of different trimesters and analysis of its clinical significance

摘要: 目的初步建立深圳市龙岗地区不同孕期健康孕妇D-二聚体参考区间,分析其临床意义。方法选取本院7810例不同孕期的孕妇和2250例非孕妇女,采用免疫比浊法,使用sysmex CS 5100仪器及配套试剂,对研究对象D-二聚体进行检测和统计学分析。结果孕早期、孕中期、孕晚期的参考区间分别为 ≤ 1.27、≤ 2.86、≤ 5.45μg/m L,明显高于对照组(≤ 0.38μg/m L)。结论初步建立龙岗地区不同孕期孕妇的D-二聚体参考区间,有助于准确有效评估孕妇的凝血和纤溶系统的功能,避免不必要的治疗,有重要的临床参考价值。

Abstract: Objective To develope the reference intervals for D-dimer of different trimesters and analyze its clinical significance.Methods The D-dimer levels of 7810 pregnant women and 2250 non-pregnant women were tested by immunoturbidimetric using sysmex CS 5100 and analyzed. Result The reference intervals of D-dimer concentration were ≤ 1.27, ≤ 2.86, ≤ 5.45μg/m L in the first, second and third trimester, respectively. They were significantly higher than those of the control group (≤ 0.38μg/m L).Conclusion Development of the reference intervals of D-dimer is useful to evaluate the coagution and fibrinolysis function of pregnancy women and avoid unnecessary treatment. It has important clinical reference value.