Abstract: Objective To investigate the expression of hWAPL in cervical cancer tissues and the relationship between hWAPL and clinicopathological features.Methods Ninety specimens of cervical cancer tissues (cervical cancer group) and 90 specimens of cervical epithelial neoplasia (CIN group) tissues were collected in our hospital from March 2015 to January 2017. The hWAPL protein expression levels of the two groups specimens were tested. The relationship between hWAPL protein and the age of cervical cancer patients, the International Union of Women (FIGO) staging, histological grade and other indicators were explored.Results The positive expression rate of hWAPL protein in cervical cancer group was 74.44% (67/90). It was significantly higher than that of CIN group (12.22%, 11/90). The difference was statistically significant (P< 0.05). The positive expression rate of hWAPL protein of cervical cancer patients with FIGO stage III, low differentiation, interstitial infiltration ≥ 1/2, lymph node metastasis, lymphvascular invasion was significantly higher than that of cervical cancer patients with stage I and II, and high differentiation, interstitial infiltration of < 1/2, no lymph node metastasis, no lymphvascular invasion. The differences were statistically significant (P< 0.05). There was no statistically significant difference in the positive expression of hWAPL protein between more than 50 years old cervical cancer patients and less than 50 year old patients (P> 0.05).Conclusion The expression of hWAPL protein in cervical cancer tissues is significantly up-regulated, and it is closely related to the occurrence and development of cervical cancer.