Abstract: Objective To understand the status of anxiety and depression and related risk factors among pregnant women in Zhangjiagang,and provide evidence for intervention.Methods Pregnant women in early,middle and late phases of pregnancy were selected and investigated using HAMA,EPDS and self-designed questionnaire by self-assessment and doctor assessment.Results The prevalence of anxiety in early,middle and late phases of pregnancy were 7.17%,4.93% and 6.55%,respectively.The prevalence of depression in early,middle and late phases of pregnancy were 8.52%,9.51% and 8.36%,respectively.The differences were not statistically significant on prevalence of depression and anxiety across 3 phases of pregnancy (depression:χ²=1.21,P>0.05;anxiety:χ²=1.21,P>0.05).The prevalence of depression was significantly higher than anxiety (χ²=4.06,P<0.05).Multivariate analysis indicated that nonresident,noises around living,fetus protection and pregnancy complication were independent risk factors of anxiety during pregnancy,while folic acid intake was protective factor of anxiety during pregnancy.Meanwhile,noises around living,fetus protection,abnormal pregnancy history and pregnancy complication were independent risk factors of depression during pregnancy,whereas,high education level was protective factor of anxiety during pregnancy.Conclusion Anxiety and depression of pregnant women exist among pregnant women in Zhangjiagang.Mental health care and routine anxiety and depression screening are needed,in order to promote early intervention and prevent psychological disorder.