Abstract: Objective To investigate the changes and significance of soluble myeloid cell-triggered receptor-1 (sTREM-1), solubleurokinase-type plasminogen activator receptor (su PAR), cortisol (Cor), interleukin-1 receptor (IL-IR1) and active protein C (APC) of children with sepsis.Methods From January 2014 to February 2017, ninety sepsis children (sepsis group), 37 noninfected children with systemic inflammatory response syndrome (NISIRS group) were selected as the sepsis group and the NISIRS group, respectively and 60 healthy children at the same period were selected as the control group. The levels of sTREM-1, su PAR, Cor, IL-IR1 and APC in the three groups were detected and compared among different sepsis patients.Results The levels of serum sTREM-1, su PAR, Cor, IL-IR1 and APC in children with sepsis were higher than those in the NISIRS group and the control group (P< 0.05). All of the levels of serum sTREM-1, su PAR, Cor, IL-IR1 and APC in the NISIRS group were higher than those in the control group (P< 0.05). The serum levels of sTREM-1, su PAR, Cor, IL-IR1 APC and PCIS in the children with septic shock were higher than those of the general sepsis group and the severe sepsis group (P< 0.05). The levels of serum sTREM-1, su PAR, Cor, ILIR1 APC and PCIS in patients with severe sepsis were significantly higher than those in the general sepsis group (P< 0.05). There was a significantly negative correlation between the serum levels of sTREM-1, su PAR, Cor, IL-IR1 and APC, and the PCIS score in the children with septic shock (P< 0.05).Conclusion The levels of sTREM-1, su PAR, Cor, IL-IR1 and APC in sepsis children were significantly higher than those in healthy children and SIRS children, and there was a certain relationship with the severity of sepsis.