Abstract: Objective To explore the effect of early sensory input on gross motor function in high-risk children with brain injury.Methods Forty-two high-risk children with brain injury (2 months to 4 months) were randomly divided into experimental group (n=21) and control group (n=21). The control group received routine rehabilitation treatment. Based on the routine treatment, the experimental group was also given early enough sensation input. After one course of treatment, the treatment effects of the experimental group and the control group were compared. Peabody gross motion assessment scales were used to evaluate children before and after treatment.Results After the treatment, the gross motor quotient of the two groups was significantly increased, and the experimental group was significantly better than the control group (P<0. 005).Conclusion Early sensory input can significantly increase the gross motor function of high-risk children with brain injury.