Study on the relationship between Kisspeptin and early unexplained abortion

Objective To explore the effect of Kisspeptin in early stages of pregnancy by detecting it's expression levels in the serum and villus tissue.Methods Immunohistochemical method was used to analyze the expression of kisspeptin in chorionic villi of normal pregnancy group (n=20) and spontaneous abortion group (n=20). The serum kisspeptin concentration of 40 pregnant women at 10 weeks of gestation was detected by enzyme-linked immunosorbent assay (ELISA).Results ① Normal pregnant women had significantly higher villus tissue kisspeptin levels (170. 3 ± 7. 134) than abortion women (198. 4 ± 5. 699) (P< 0. 001). ②The results of ELISA showed that the serum concentration of Kisspeptin in normal pregnancy group increased with the increase of gestational age,while the serum concentration of kisspeptin in spontaneous abortion group decreased gradually with gestational age.Conclusion Kisspeptin plays an important role in embryo implantation and development in early pregnancy,and can be used as an indicator to predictpregnancy outcome.