Study on the relationship between vitamin D and gestational diabetes mellitus

Objective To study the correlation between vitamin D and gestational diabetes mellitus (GDM).Methods The clinical data of 86 patients with GDM admitted from August 2016 to September 2017 were retrospectively analyzed. They were set as the observation group and 86 normal pregnant women were selected as the control group. All pregnant women were tested for vitamin D,and the correlation between gestational diabetes mellitus and vitamin D level was analyzed.Results There was no significant difference in the baseline data of gestational weeks and family history of diabetes between the two groups (P > 0. 05). The age of the observation group was older than that of the control group. The BMI,FBG,2 h PBG,FINS and HOMA-IR levels of the observation group were higher than those of the control group. The levels of vitamin D and HOMA-IS of the observation group were lower than those of the control group (P< 0. 05). Pearson correlation analysis with age,BMI,FPG,2 hPBG,FINS,HOMA-IR and HOMA-IS as independent variables showed that FPG,2 h PBG,FINS,HOMA-IR and HOMA-IS were all correlated with vitamin D. FPG,2 h PBG,FINS,HOMA-IR were negatively correlated with vitamin D,and HOMA-IS was positively correlated with vitamin D (P< 0. 05).Conclusion Vitamin D is correlated with GDM. Serum vitamin D level of pregnant women GDM is lower than that of normal pregnant women. Vitamin D deficiency can participate in the occurrence and development of GDM. The mechanism may be to increase insulin resistance.