Objective To analyze the factors associated with decreased ovarian reserve(DOR) among infertile women.
Methods Totally 214 infertile women were recruited from January 2019 to January 2022 in Nanyang first people's hospital, Henan Province and were divided into DOR group (n = 126) and non-DOR group (n = 88) based on their ovarian reserve function. Clinical data of 2 groups were collected. Age, place of residence, education level, work situation, duration of daily labor, sleeping hours per day, body mass index (BMI), years of infertility, age at first pregnancy, number of antral follicles (AFC), serum anti-Mllerian hormone (AMH) level, serum inhibin B (INHB) level, serum interleukin-4 (IL-4) level, serum IL-10 level, number of ovulation induction cycles, menstrual profile and pelvic inflammatory disease were compared between 2 groups. Logistic regression was used to analyze the factors associated with DOR among infertile women.
Results Age, years of infertility, serum INHB level, serum IL-4 level, serum IL-10 level, number of ovulation induction cycles, menstrual status, pelvic inflammatory condition were factors associated with DOR among infertile women (P < 0.05). Logistic regression analysis showed that age > 35 years, > 4.84 years of infertility, number of ovulation induction cycles > 1.15 times, irregular menstrual cycle, pelvic inflammatory disease were risk factors, while AFC ≥ 5 times, serum AMH level ≥ 2 ng/mL, serum INHB level ≥ 18.22 pg/mL, serum IL-4 level > 129.44 ng/L, serum IL-10 level > 28.09 ng/L were protective factors for DOR among infertile women.
Conclusion The factors contributing to DOR among infertile women are age, years of infertility, AFC, serum AMH level, serum INHB level, serum VEGF level, serum IL-4 level, serum IL-10 level, number of ovulation induction cycles, menstrual status and pelvic inflammatory conditions. Corresponding diagnosis and treatment measures should be developed to further improve their prognosis.
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